Reproduction Abstracts

Introduction: Proliferation of granulosa cells (GCs) is essential for oocyte growth toward ovulation. Extreme proliferation of GCs is taken place under hypoxic condition due to lack of vascularization in the follicles. However, the mechanisms underlying proliferation of GCs under hypoxia have not been elucidated. In the present study, we examined the effect of low oxygen level on molecular background of cellular proliferation in bovine GCs.Methods: Bovin...